A systems biology activity at the two Amsterdam Universities, deriving from the research area systems biology of the University of Amsterdam.
SysBA (www.SysBA.NL) is a systems biology/systems medicine centre at the two collaborating Amsterdam Universities and their institutes/centres SILS and AIMMS. It is part of the Research priority area Systems Biology of the University of Amsterdam (UvA). SysBA is active on both the experimental and the modelling sides of the life sciences, focusing on their integration. It connects with systems biology centres in Luxembourg, Manchester, and Milano.
SysBioAmsterdam hosts the Dutch hub (ISBE.NL) for the Infrastrcuture Systems Biology Europe (ISBE). It provides some of the first ISBE services such as modelling, certain experimentation, advice on standardization and maintains a model repository.
4M4U: the Make-Me-My-Model service for you
4M4U models for biologists, biotechnologists, and clinicians who would like to use network models to address issues of applied or fundamental importance. In its CORBEL activity, 4M also involves other European Life Science Research Infrastructures, such as those on bioinformatics, imaging and high-throughput experimentation.
SysBioAmsterdam is setting up a facility at which genome-wide metabolic maps will be made for human individuals on the basis of their SNP pattern or whole genome sequence. The implications of the features of the individual's genome sequence and available funtional genomic data will be estimated by computation.
SysBioAmsterdam is home to IMSEC, the Immune Systems Ecology Centre, which implements ecology principles to immunology and immunological principles to ecology.
A recent results has been a study of possible systems biological remediations of arsenic poisoning of drinking waters (info).
SysBioAmsterdam is major hub of the JWS model repository driven by Jacky Snoep
Dynamic metabolic maps and models
Metabolic and hierarchical control and regulation analysis
Epigenetics and genome structure
Signal transduction
Multifactorial disease such as Parkinson’s disease, obesity and cancer
Cell cycle
Non-equilibrium thermodynamics
Systems ecology
Systems immunology
Differential network-based drug design
SysBioAmsterdam aims at providing service both to life scientists who appreciate that systems biology methods may accelerate their science and applications, and to the genral public. The availability of data and test cases will greatly propel scientific developmenst in this area.
If you are interested in the services offered by SysBio Amsterdam or in joiing in its activities, do let us know at h.v.westerhoff at uva.nl